![]() ![]() Don’t drive or use machinery for 4-5 hours after taking melatonin. But it can cause some side effects including headache, sleepiness, dizziness, and nausea. Melatonin is possibly safe when taken long-term. When taken by mouth: Melatonin is likely safe for most adults when used short-term. There is interest in using melatonin for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful. Taking melatonin by mouth doesn’t seem to reduce symptoms of depression, and might make symptoms worse in some people. Taking melatonin by mouth at bedtime doesn’t reduce withdrawal symptoms in people with insomnia who have stopped taking these drugs.
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